Title : Metformin counters both lipolytic/inflammatory agents-decreased hormone sensitive lipase phosphorylation at Ser-554 and -induced lipolysis in human adipocytes.

Pub. Date : 2011 Oct

PMID : 21338323






1 Functional Relationships(s)
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1 Pre-incubation with metformin (24 h, 1 mM) inhibited forskolin-, isoproterenol-, IBMX-, LPS-, IL-1beta- and TNF-alpha-induced glycerol release and prevented p(Ser554)HSL decrease and p(Ser-552)HSL increase due to lipolytic and inflammatory agents. Isoproterenol tumor necrosis factor Homo sapiens