Title : Group II metabotropic glutamate receptor agonist ameliorates MK801-induced dysfunction of NMDA receptors via the Akt/GSK-3β pathway in adult rat prefrontal cortex.

Pub. Date : 2011 May

PMID : 21326193






2 Functional Relationships(s)
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1 This effect was attributable to the direct regulatory action of LY379268 on NMDA receptors via activation of the Akt/GSK-3beta signaling pathway. LY 379268 glycogen synthase kinase 3 beta Rattus norvegicus
2 As occurs with the antipsychotic drug clozapine, acute treatment with LY379268 significantly increased the expression and phosphorylation of NMDA receptors, as well as Akt and GSK-3beta. LY 379268 glycogen synthase kinase 3 beta Rattus norvegicus