Title : The neuroprotective action of pyrroloquinoline quinone against glutamate-induced apoptosis in hippocampal neurons is mediated through the activation of PI3K/Akt pathway.

Pub. Date : 2011 Apr 1

PMID : 21320517






1 Functional Relationships(s)
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1 And inhibition of phosphatidylinositol-3-kinase (PI3K)/Akt cascade by LY294002 and wortmannin significantly blocked the protective effects of PQQ, and alleviated the increase in Bcl-2/Bax ratio. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one BCL2 associated X, apoptosis regulator Homo sapiens