Title : The chemotherapy metabolite acrolein upregulates thrombin generation and impairs the protein C anticoagulant pathway in animal-based and cell-based models.

Pub. Date : 2011 Apr

PMID : 21320281






2 Functional Relationships(s)
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1 METHODS: Thrombin and activated protein C (APC) generation were measured in defibrinated plasma exposed to acrolein-treated endothelial and smooth muscle cells. Acrolein coagulation factor II Mus musculus
2 RESULTS: Exposure of acrolein-treated endothelial and smooth muscle cells to defibrinated plasma increased thrombin generation in the plasma. Acrolein coagulation factor II Mus musculus