Title : Lipoic acid ameliorates arsenic trioxide-induced HO-1 expression and oxidative stress in THP-1 monocytes and macrophages.

Pub. Date : 2011 Apr 25

PMID : 21315065






2 Functional Relationships(s)
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1 We found that a non-lethal concentration of arsenic trioxide (1 muM) significantly induced the expression of heme oxygenase-1 (HO-1), a response biomarker to arsenic, without stimulating measurable superoxide production. Arsenic Trioxide latexin Homo sapiens
2 In addition, low concentrations of arsenic trioxide (1 and 2.5 muM) markedly inhibited monocyte-to-macrophage differentiation and expression of macrophage markers. Arsenic Trioxide latexin Homo sapiens