Title : Novel inhibitors of glyceraldehyde-3-phosphate dehydrogenase: covalent modification of NAD-binding site by aromatic thiols.

Pub. Date : 2010 Dec

PMID : 21314614






2 Functional Relationships(s)
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1 Novel inhibitors of glyceraldehyde-3-phosphate dehydrogenase: covalent modification of NAD-binding site by aromatic thiols. NAD glyceraldehyde-3-phosphate dehydrogenase Oryctolagus cuniculus
2 Potential GAPDH inhibitors were screened in silico, and three compounds with high affinity to the NAD-binding site and theoretically capable of forming a disulfide bond with amino acid residue Cys149 were found among cysteine and glutathione derivatives. NAD glyceraldehyde-3-phosphate dehydrogenase Oryctolagus cuniculus