Title : Nitric oxide effects depend on different mechanisms in different regions of the rat heart.

Pub. Date : 2012 Jan

PMID : 21311889






3 Functional Relationships(s)
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1 The NO donor diethylamine NONOate (DEA/NO) (0.1-100 muM) depressed the resting and developed tensions, as well as the sinus rate, of the right atrium. dea latexin Homo sapiens
2 The effect of DEA/NO on contractions of the right atrium was blocked by the soluble guanylate cyclase (sGC) inhibitor, ODQ (1H-[1,2,4]oxadiazolo[4,3-alpha]quinoxalin-1-one) (10 muM). dea latexin Homo sapiens
3 The ATP-sensitive potassium channel (K(ATP)) blocker glyburide (3 muM) reversed DEA/NO-induced decreases in the resting tension. dea latexin Homo sapiens