Pub. Date : 2010 Dec
PMID : 21311676
3 Functional Relationships(s)Download |
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Sentence | Compound Name | Protein Name | Organism |
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| 1 | Melatonin increased the expressions of p53, p21, and p27. | Melatonin | H3 histone pseudogene 16 | Homo sapiens | ||
| 2 | Treatment with mitogen-activated protein kinase (MAPK) inhibitors, PD98059 (ERK inhibitor), SP600125 (JNK inhibitor) and SB202190 (p38 inhibitor), confirmed that the melatonin-induced apoptosis was p21-dependent, but ERK-independent. | Melatonin | H3 histone pseudogene 16 | Homo sapiens | ||
| 3 | With the co-treatment of PD98059 and melatonin, the expression of p-p53, p21, and MDM2 did not decrease. | Melatonin | H3 histone pseudogene 16 | Homo sapiens | ||