Title : Immunosuppressor FK506 increases endoglin and activin receptor-like kinase 1 expression and modulates transforming growth factor-β1 signaling in endothelial cells.

Pub. Date : 2011 May

PMID : 21310938






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 We report the efficacy of tacrolimus (FK506) in increasing ENG and ALK1 expression. Tacrolimus activin A receptor like type 1 Homo sapiens
2 We report the efficacy of tacrolimus (FK506) in increasing ENG and ALK1 expression. Tacrolimus activin A receptor like type 1 Homo sapiens
3 Here, we find that the immunosuppressor FK506 increases the protein and mRNA expression of ENG and ALK1 in cultured endothelial cells and enhances the TGF-beta1/ALK1 signaling pathway and endothelial cell functions like tubulogenesis and migration. Tacrolimus activin A receptor like type 1 Homo sapiens
4 Here, we find that the immunosuppressor FK506 increases the protein and mRNA expression of ENG and ALK1 in cultured endothelial cells and enhances the TGF-beta1/ALK1 signaling pathway and endothelial cell functions like tubulogenesis and migration. Tacrolimus activin A receptor like type 1 Homo sapiens