Title : A critical life-supporting role for cystathionine γ-lyase in the absence of dietary cysteine supply.

Pub. Date : 2011 May 15

PMID : 21310231






7 Functional Relationships(s)
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1 This study examined the important relationship between cystathionine gamma-lyase (CSE) functionality and cysteine supply for normal growth and life span. Cysteine cystathionase (cystathionine gamma-lyase) Mus musculus
2 This study examined the important relationship between cystathionine gamma-lyase (CSE) functionality and cysteine supply for normal growth and life span. Cysteine cystathionase (cystathionine gamma-lyase) Mus musculus
3 CSE-KO mice fed a cysteine-limited diet exhibited growth retardation; decreased levels of cysteine, glutathione, and H2S; and increased plasma homocysteine level. Cysteine cystathionase (cystathionine gamma-lyase) Mus musculus
4 CSE-KO mice fed a cysteine-limited diet exhibited growth retardation; decreased levels of cysteine, glutathione, and H2S; and increased plasma homocysteine level. Cysteine cystathionase (cystathionine gamma-lyase) Mus musculus
5 On the other hand, supplementation of cysteine in the drinking water of the CSE-KO mice significantly increased plasma cysteine and glutathione levels. Cysteine cystathionase (cystathionine gamma-lyase) Mus musculus
6 On the other hand, supplementation of cysteine in the drinking water of the CSE-KO mice significantly increased plasma cysteine and glutathione levels. Cysteine cystathionase (cystathionine gamma-lyase) Mus musculus
7 In conclusion, CSE is critical for cysteine biosynthesis through the transsulfuration pathway and the combination of CSE deficiency and lack of dietary cysteine supply would threaten life sustainability. Cysteine cystathionase (cystathionine gamma-lyase) Mus musculus