Title : Cigarette smoke and α,β-unsaturated aldehydes elicit VEGF release through the p38 MAPK pathway in human airway smooth muscle cells and lung fibroblasts.

Pub. Date : 2011 Jun

PMID : 21306579






2 Functional Relationships(s)
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1 CSE-evoked VEGF release was mimicked by its component acrolein at concentrations (10-100 microM) found in CSE, and prevented by the antioxidant and alpha,beta-unsaturated aldehyde scavenger, N-acetylcysteine (NAC). Acrolein vascular endothelial growth factor A Homo sapiens
2 Both CSE and acrolein (30 microM) induced VEGF mRNA expression in ASMC cultures, suggesting an effect at transcriptional level. Acrolein vascular endothelial growth factor A Homo sapiens