Pub. Date : 2011 Apr
PMID : 21297032
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | However, in a previous study we reported that the protein kinase C (PKC)-agonist PMA could induce a sustained activation of Nox5 that was independent of calcium changes. | Tetradecanoylphorbol Acetate | NADPH oxidase 5 | Homo sapiens |
| 2 | The inhibition of MEK1 using PD-98059 and U-0126 significantly reduced the phosphorylation and activity of Nox5 in response to PMA but not to the calcium-mobilizing stimulus ionomycin. | Tetradecanoylphorbol Acetate | NADPH oxidase 5 | Homo sapiens |
| 3 | These results suggest that the MEK/ERK1/2 pathway is necessary but not sufficient to regulate the PMA-dependent activation of Nox5. | Tetradecanoylphorbol Acetate | NADPH oxidase 5 | Homo sapiens |