Pub. Date : 2011 Apr 7
PMID : 21297000
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Aortic and renal tissues have uncoupled eNOS and increased reactive oxygen species (ROS) in PRCP(gt/gt) mice as detected by dihydroethidium or Amplex Red fluorescence or lucigenin luminescence. | Reactive Oxygen Species | prolylcarboxypeptidase (angiotensinase C) | Mus musculus |
| 2 | Aortic and renal tissues have uncoupled eNOS and increased reactive oxygen species (ROS) in PRCP(gt/gt) mice as detected by dihydroethidium or Amplex Red fluorescence or lucigenin luminescence. | Reactive Oxygen Species | prolylcarboxypeptidase (angiotensinase C) | Mus musculus |
| 3 | The importance of ROS is evidenced by the fact that treatment of PRCP(gt/gt) mice with antioxidants (mitoTEMPO, apocynin, Tempol) abrogates the hypertensive, prothrombotic phenotype. | Reactive Oxygen Species | prolylcarboxypeptidase (angiotensinase C) | Mus musculus |
| 4 | Further, PRCP siRNA treatment of endothelial cells shows increased ROS and uncoupled eNOS and decreased protein C activation because of thrombomodulin inactivation. | Reactive Oxygen Species | prolylcarboxypeptidase (angiotensinase C) | Mus musculus |
| 5 | Collectively, our studies identify PRCP as a novel regulator of vascular ROS and homeostasis. | Reactive Oxygen Species | prolylcarboxypeptidase (angiotensinase C) | Mus musculus |