Title : Human neuroglobin functions as a redox-regulated nitrite reductase.

Pub. Date : 2011 May 20

PMID : 21296891






1 Functional Relationships(s)
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1 Replacement of the distal histidine by leucine or glutamine leads to a stable five-coordinated geometry; these neuroglobin mutants reduce nitrite to NO ~2000 times faster than the wild type, whereas mutation of either Cys-55 or Cys-46 to alanine stabilizes the six-coordinate structure and slows the reaction. Histidine neuroglobin Homo sapiens