Title : Costunolide stimulates the function of osteoblastic MC3T3-E1 cells.

Pub. Date : 2011 Jun

PMID : 21296696






3 Functional Relationships(s)
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1 The effect of costunolide in increasing ALP activity was prevented by the presence of ICI182780, PD98059, SB203580, or rotrelin, suggesting that the effect of costunolide on ALP activity might be mediated from ER, ERK, p38, and PKC. costunolide mitogen-activated protein kinase 14 Mus musculus
2 The effect of costunolide in increasing ALP activity was prevented by the presence of ICI182780, PD98059, SB203580, or rotrelin, suggesting that the effect of costunolide on ALP activity might be mediated from ER, ERK, p38, and PKC. costunolide mitogen-activated protein kinase 14 Mus musculus
3 The effect of costunolide in increasing collagen content was prevented by the presence of LY294002, PD98059, SB203580, SP600125, or rotrelin, suggesting that the effect of costunolide on collagen synthesis might be mediated from PI3K, ERK, p38, JNK, and PKC. costunolide mitogen-activated protein kinase 14 Mus musculus