Title : Ectodomain shedding and autocleavage of the cardiac membrane protease corin.

Pub. Date : 2011 Mar 25

PMID : 21288900






1 Functional Relationships(s)
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1 Using protease inhibitors, ionomycin and phorbol myristate acetate stimulation, small interfering RNA knockdown, and site-directed mutagenesis, we found that ADAM10 was primarily responsible for shedding corin in its juxtamembrane region to release the ~180-kDa fragment, corresponding to the near-entire extracellular region. Tetradecanoylphorbol Acetate ADAM metallopeptidase domain 10 Homo sapiens