Pub. Date : 2011 May
PMID : 21287141
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Glucose oscillations, more than constant high glucose, induce p53 activation and a metabolic memory in human endothelial cells. | Glucose | tumor protein p53 | Homo sapiens |
| 2 | Evaluation of the effects of exposure of HUVECs to oscillating high glucose on the induction of markers of oxidative stress and DNA damage (phospho-gamma-histone H2AX and PKCdelta) and onset of metabolic memory, and the possible role of the tumour suppressor transcriptional factor p53 is of pivotal interest. | Glucose | tumor protein p53 | Homo sapiens |
| 3 | Transcriptional activity of p53 was also evaluated in the first 24 h after high glucose exposure. | Glucose | tumor protein p53 | Homo sapiens |
| 4 | Transcriptional activity of p53 peaked 6 h after glucose exposure, showing a predicted oscillatory behaviour. | Glucose | tumor protein p53 | Homo sapiens |
| 5 | Hyperactivation of p53 during glucose oscillation might be due to the absence of consistent feedback inhibition during each glucose spike and might account for the worse outcome of this condition. | Glucose | tumor protein p53 | Homo sapiens |