Title : Novel HIV-1 protease inhibitors (PIs) containing a bicyclic P2 functional moiety, tetrahydropyrano-tetrahydrofuran, that are potent against multi-PI-resistant HIV-1 variants.

Pub. Date : 2011 Apr

PMID : 21282450






1 Functional Relationships(s)
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Protein Name
Organism
1 Modeling analyses revealed that GRL-1398 had greater overall hydrogen bonding and hydrophobic interactions than GRL-1388 and DRV and that GRL-1388 and -1398 had hydrogen bonding interactions with the main chain of the active-site amino acids (Asp29 and Asp30) of protease. Hydrogen nuclear receptor subfamily 3 group C member 1 Homo sapiens