Title : Enhancement of proton conductance by mutations of the selectivity filter of aquaporin-1.

Pub. Date : 2011 Apr 8

PMID : 21277313






3 Functional Relationships(s)
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1 Both AQP1 mutants exhibit a surprising cooperative effect leading to a reduction in the free-energy barrier for proton permeation around the NPA region due to altered water configurations in the SF region, with AQP1-R195S having a higher conductance than AQP1-R195V. Water aquaporin 1 (Colton blood group) L homeolog Xenopus laevis
2 Both AQP1 mutants exhibit a surprising cooperative effect leading to a reduction in the free-energy barrier for proton permeation around the NPA region due to altered water configurations in the SF region, with AQP1-R195S having a higher conductance than AQP1-R195V. Water aquaporin 1 (Colton blood group) L homeolog Xenopus laevis
3 Both AQP1 mutants exhibit a surprising cooperative effect leading to a reduction in the free-energy barrier for proton permeation around the NPA region due to altered water configurations in the SF region, with AQP1-R195S having a higher conductance than AQP1-R195V. Water aquaporin 1 (Colton blood group) L homeolog Xenopus laevis