Title : Diabetic downregulation of Nrf2 activity via ERK contributes to oxidative stress-induced insulin resistance in cardiac cells in vitro and in vivo.

Pub. Date : 2011 Feb

PMID : 21270272






2 Functional Relationships(s)
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1 Forced activation of Nrf2 by adenoviral over-expression of Nrf2 inhibited the increased ERK activity and recovered the blunted insulin sensitivity on glucose uptake in cardiomyocytes that were chronically treated with H(2)O(2). Water nuclear factor, erythroid derived 2, like 2 Mus musculus
2 Forced activation of Nrf2 by adenoviral over-expression of Nrf2 inhibited the increased ERK activity and recovered the blunted insulin sensitivity on glucose uptake in cardiomyocytes that were chronically treated with H(2)O(2). Water nuclear factor, erythroid derived 2, like 2 Mus musculus