Title : Saccharomyces cerevisiae Bat1 and Bat2 aminotransferases have functionally diverged from the ancestral-like Kluyveromyces lactis orthologous enzyme.

Pub. Date : 2011 Jan 18

PMID : 21267457






2 Functional Relationships(s)
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1 Under respiratory conditions, in the presence of ammonium and BCAAs the bat1Delta bat2Delta double mutant shows impaired growth, indicating that Bat1 and Bat2 could play redundant roles. Amino Acids, Branched-Chain branched-chain-amino-acid transaminase BAT2 Saccharomyces cerevisiae S288C
2 CONCLUSIONS: Our study shows that BAT1 and BAT2 differential expression and subcellular relocalization has resulted in the distribution of the biosynthetic and catabolic roles of the ancestral BCAT in two isozymes improving BCAAs metabolism and constituting an adaptation to facultative metabolism. Amino Acids, Branched-Chain branched-chain-amino-acid transaminase BAT2 Saccharomyces cerevisiae S288C