Pub. Date : 2011 May 30
PMID : 21256123
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The catalytic efficiencies for metabolism of acrolein by Aldh1a1 was comparable to that of Aldh3a1 (V(max)/K(m)=23). | Acrolein | aldehyde dehydrogenase family 1, subfamily A1 | Mus musculus |
| 2 | We demonstrated that knockdown of Aldh1a1 expression by siRNA caused Hepa-1c1c7 cells to be more sensitive to acrolein-induced cell death and resulted in increased accumulation of acrolein-protein adducts and caspase 3 activation. | Acrolein | aldehyde dehydrogenase family 1, subfamily A1 | Mus musculus |
| 3 | In addition, hepatic cytosolic ALDH activity was induced by acrolein when 1mM NAD(+) was used as cofactor, suggesting an Aldh1a1-protective mechanism against acrolein toxicity in mice liver. | Acrolein | aldehyde dehydrogenase family 1, subfamily A1 | Mus musculus |
| 4 | In addition, hepatic cytosolic ALDH activity was induced by acrolein when 1mM NAD(+) was used as cofactor, suggesting an Aldh1a1-protective mechanism against acrolein toxicity in mice liver. | Acrolein | aldehyde dehydrogenase family 1, subfamily A1 | Mus musculus |
| 5 | In addition, hepatic cytosolic ALDH activity was induced by acrolein when 1mM NAD(+) was used as cofactor, suggesting an Aldh1a1-protective mechanism against acrolein toxicity in mice liver. | Acrolein | aldehyde dehydrogenase family 1, subfamily A1 | Mus musculus |
| 6 | In addition, hepatic cytosolic ALDH activity was induced by acrolein when 1mM NAD(+) was used as cofactor, suggesting an Aldh1a1-protective mechanism against acrolein toxicity in mice liver. | Acrolein | aldehyde dehydrogenase family 1, subfamily A1 | Mus musculus |