Pub. Date : 2011 Jun
PMID : 21250978
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BACKGROUND AND PURPOSE: 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone (RH1) is a bioreductive agent that is activated by the two-electron reductase NAD(P)H quinone oxidoreductase 1 (NQO1). | 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone | NAD(P)H quinone dehydrogenase 1 | Homo sapiens |
| 2 | BACKGROUND AND PURPOSE: 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone (RH1) is a bioreductive agent that is activated by the two-electron reductase NAD(P)H quinone oxidoreductase 1 (NQO1). | 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone | NAD(P)H quinone dehydrogenase 1 | Homo sapiens |
| 3 | EXPERIMENTAL APPROACH: 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone-induced apoptosis and related signalling pathways in NQO1-negative and NQO1-overexpressing cells were evaluated. | 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone | NAD(P)H quinone dehydrogenase 1 | Homo sapiens |
| 4 | EXPERIMENTAL APPROACH: 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone-induced apoptosis and related signalling pathways in NQO1-negative and NQO1-overexpressing cells were evaluated. | 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone | NAD(P)H quinone dehydrogenase 1 | Homo sapiens |
| 5 | KEY RESULTS: 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone induced apoptosis and clonogenic death, dependent on NQO1 and p53. | 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone | NAD(P)H quinone dehydrogenase 1 | Homo sapiens |
| 6 | CONCLUSIONS AND IMPLICATIONS: 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone activated JNK, resulting in mitochondria-mediated apoptotic cell death that was NQO1-dependent. | 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone | NAD(P)H quinone dehydrogenase 1 | Homo sapiens |