Pub. Date : 2011 Jul
PMID : 21246637
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Evodiamine inhibits 12-O-tetradecanoylphorbol-13-acetate-induced activator protein 1 transactivation and cell transformation in human hepatocytes. | Tetradecanoylphorbol Acetate | JunB proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 2 | The Chang/AP-1 cells were treated with E. rutaecarpa and its bioactive constituents, and challenged with the AP-1 stimulator 12-O-tetradecanoylphorbol-13- acetate (TPA). | Tetradecanoylphorbol Acetate | JunB proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 3 | The present study showed that the methanol extract of E. rutaecarpa decreased the TPA-induced AP-1 transactivation in Chang/AP-1 cells, with an EC50 value of 24.72 mug/mL. | Tetradecanoylphorbol Acetate | JunB proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 4 | The present study showed that the methanol extract of E. rutaecarpa decreased the TPA-induced AP-1 transactivation in Chang/AP-1 cells, with an EC50 value of 24.72 mug/mL. | Tetradecanoylphorbol Acetate | JunB proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 5 | EVO inhibited the TPA-induced AP-1 transactivation and colony formation, with EC50 values of 82 muM and 8.2 muM, respectively. | Tetradecanoylphorbol Acetate | JunB proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 6 | These results suggested that EVO treatment suppressed the TPA-induced AP-1 activity via the ERKs pathway. | Tetradecanoylphorbol Acetate | JunB proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |