Title : Regulation of diamine oxidase expression by ornithine decarboxylase in isolated rat small bowel enterocytes.

Pub. Date : 1990

PMID : 2124562






4 Functional Relationships(s)
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1 In order to investigate a possible regulation of DAO expression by ODC, we studied the effect of difluoromethylornithine (DFMO), a selective, irreversible inhibitor of ODC, on DAO activity in isolated rat small bowel enterocytes. Eflornithine amine oxidase, copper containing 1 Rattus norvegicus
2 In order to investigate a possible regulation of DAO expression by ODC, we studied the effect of difluoromethylornithine (DFMO), a selective, irreversible inhibitor of ODC, on DAO activity in isolated rat small bowel enterocytes. Eflornithine amine oxidase, copper containing 1 Rattus norvegicus
3 Our data demonstrate that in isolated small bowel enterocytes ODC inhibition by 10 mM DFMO reduced DAO activity by 53%, suggesting that, in our experimental conditions, ODC plays a regulatory role on DAO expression. Eflornithine amine oxidase, copper containing 1 Rattus norvegicus
4 Our data demonstrate that in isolated small bowel enterocytes ODC inhibition by 10 mM DFMO reduced DAO activity by 53%, suggesting that, in our experimental conditions, ODC plays a regulatory role on DAO expression. Eflornithine amine oxidase, copper containing 1 Rattus norvegicus