Pub. Date : 1990 Sep
PMID : 2122528
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Spontaneous mutants of mouse FM3A cells (AC1, AC2, and AC3), highly resistant to aphidicolin (3000-, 2500-, and 300-fold increase in resistance, respectively), were isolated by multistep selection. | Aphidicolin | adenylate cyclase 3 | Mus musculus |
| 2 | The DNA polymerase activity in nuclear extracts in AC1 and AC3, but not AC2, was resistant to aphidicolin. | Aphidicolin | adenylate cyclase 3 | Mus musculus |
| 3 | Partially purified DNA polymerase alpha from AC3, but not from AC1 or AC2, showed resistance to aphidicolin. | Aphidicolin | adenylate cyclase 3 | Mus musculus |
| 4 | The apparent Ki value for aphidicolin of AC3 polymerase alpha was three to four times that of the enzyme from the parent cells, but the apparent Km values of the enzyme for dCTP and dTTP were normal. | Aphidicolin | adenylate cyclase 3 | Mus musculus |