Title : The S140G KCNQ1 atrial fibrillation mutation affects 'I(KS)' profile during both atrial and ventricular action potentials.

Pub. Date : 2010 Dec

PMID : 21224508






1 Functional Relationships(s)
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1 Here the action potential (AP) voltage clamp technique was used to elucidate the effect of S140G KCNQ1 on the profile of recombinant I(Ks) during atrial and ventricular APs applied to KCNQ1+KCNE1 expressing CHO cells, at 37 C. Under conventional voltage clamp the S140G KCNQ1 mutation shifted voltage-dependent activation by -62 mV, with a marked instantaneous current component evident on membrane depolarisation. Potassium potassium voltage-gated channel subfamily E member 1 Cricetulus griseus