Title : Serine racemase and the serine shuttle between neurons and astrocytes.

Pub. Date : 2011 Nov

PMID : 21224019






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Synthesis of d-serine is carried out by serine racemase (SR), a pyridoxal 5"-phosphate-dependent enzyme. D-serine serine racemase Homo sapiens
2 Synthesis of d-serine is carried out by serine racemase (SR), a pyridoxal 5"-phosphate-dependent enzyme. D-serine serine racemase Homo sapiens
3 I propose a role for SR in a novel form of astrocyte-neuron communication-the "serine shuttle", whereby astrocytes synthesize and export l-serine required for the synthesis of d-serine by the predominantly neuronal SR. D-serine serine racemase Homo sapiens
4 The higher content of d-serine in astrocytes appears to be related to increased d-serine stability, for their low SR expression will prevent substantial d-serine metabolism via alpha,beta-elimination. D-serine serine racemase Homo sapiens