Pub. Date : 2011 Apr
PMID : 21223972
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Parthenolide inhibits STAT3 signaling and attenuates angiotensin II-induced left ventricular hypertrophy via modulation of fibroblast activity. | parthenolide | signal transducer and activator of transcription 3 | Rattus norvegicus |
| 2 | Parthenolide has shown promise in treatment of various cancers via inhibition of the transcription factor signal transducer and activator of transcription 3 (STAT3). | parthenolide | signal transducer and activator of transcription 3 | Rattus norvegicus |
| 3 | Parthenolide has shown promise in treatment of various cancers via inhibition of the transcription factor signal transducer and activator of transcription 3 (STAT3). | parthenolide | signal transducer and activator of transcription 3 | Rattus norvegicus |
| 4 | Parthenolide treatment had no effect on ejection fraction, but abolished the activation of STAT3 and reduced the Ang II-induced LVH (LV posterior wall thickness in end-diastole: 2.28 +- 0.12 mm vs. 1.80 +- 0.06 mm, P<0.001). | parthenolide | signal transducer and activator of transcription 3 | Rattus norvegicus |
| 5 | We conclude that pharmacological inhibition of STAT3 signaling by parthenolide has favorable effects on pressure overload-induced LVH through attenuation of fibroblast activation. | parthenolide | signal transducer and activator of transcription 3 | Rattus norvegicus |