Title : Synergy between glutathione peroxidase-1 and astrocytic growth factors suppresses free radical generation and protects dopaminergic neurons against 6-hydroxydopamine.

Pub. Date : 2011 Apr

PMID : 21222532






7 Functional Relationships(s)
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1 Synergy between glutathione peroxidase-1 and astrocytic growth factors suppresses free radical generation and protects dopaminergic neurons against 6-hydroxydopamine. Oxidopamine glutathione peroxidase 1 Homo sapiens
2 This study examined the potency of glutathione peroxidase-1 (GPX-1) to protect dopaminergic neurons against toxicity induced by the parkinsonian neurotoxin 6-hydroxydopamine (6-OHDA). Oxidopamine glutathione peroxidase 1 Homo sapiens
3 This study examined the potency of glutathione peroxidase-1 (GPX-1) to protect dopaminergic neurons against toxicity induced by the parkinsonian neurotoxin 6-hydroxydopamine (6-OHDA). Oxidopamine glutathione peroxidase 1 Homo sapiens
4 This study examined the potency of glutathione peroxidase-1 (GPX-1) to protect dopaminergic neurons against toxicity induced by the parkinsonian neurotoxin 6-hydroxydopamine (6-OHDA). Oxidopamine glutathione peroxidase 1 Homo sapiens
5 This study examined the potency of glutathione peroxidase-1 (GPX-1) to protect dopaminergic neurons against toxicity induced by the parkinsonian neurotoxin 6-hydroxydopamine (6-OHDA). Oxidopamine glutathione peroxidase 1 Homo sapiens
6 In the pLV-GPX1-infected cells, we also detected significantly increased neuronal survival and resistance to 6-OHDA-mediated toxicity compared to our controls (75 +- 4% versus 51 +- 7%, p < 0.001). Oxidopamine glutathione peroxidase 1 Homo sapiens
7 We found the treated pLV-GPX1-infected neurons even more significantly resistant to 6-OHDA toxicity compared to their untreated counterparts (86 +- 5% versus 75 +- 4%, p < 0.001). Oxidopamine glutathione peroxidase 1 Homo sapiens