Title : Arginase 1 contributes to diminished coronary arteriolar dilation in patients with diabetes.

Pub. Date : 2011 Mar

PMID : 21217072






3 Functional Relationships(s)
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1 We found that the endothelium-dependent agonist ACh elicited a diminished vasodilation and caused constriction to the highest ACh concentration (0.1 muM) with a similar magnitude in patients with (18 +- 8%) and without (17 +- 9%) DM. Acetylcholine latexin Homo sapiens
2 We found that the endothelium-dependent agonist ACh elicited a diminished vasodilation and caused constriction to the highest ACh concentration (0.1 muM) with a similar magnitude in patients with (18 +- 8%) and without (17 +- 9%) DM. Acetylcholine latexin Homo sapiens
3 Interestingly, we found that the presence of N(G)-hydroxy-L-arginine (10 muM), a selective inhibitor of arginase or application of L-arginine (3 mM), restored ACh-induced coronary dilations only in patients with DM (to 47 +- 6% and to 40 +- 19%, respectively) but not in subjects without DM. Acetylcholine latexin Homo sapiens