Pub. Date : 2011 Mar
PMID : 21214549
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A body of evidence is growing to suggest that Abeta binds to ganglioside on neuronal membranes, and then, is converted to an endogenous seed with an altered conformation (ganglioside-bound Abeta, GAbeta) for amyloid fibril formation in the brain. | Gangliosides | alpha glucosidase | Homo sapiens |
| 2 | A body of evidence is growing to suggest that Abeta binds to ganglioside on neuronal membranes, and then, is converted to an endogenous seed with an altered conformation (ganglioside-bound Abeta, GAbeta) for amyloid fibril formation in the brain. | Gangliosides | alpha glucosidase | Homo sapiens |
| 3 | Notably, the risk factors for the development of AD, including aging and apolipoprotein E4, likely facilitate the formation of ganglioside clusters in lipid raft-like membrane microdomains at pre-synaptic terminals, which provide a favorable milieu for the GAbeta generation. | Gangliosides | alpha glucosidase | Homo sapiens |
| 4 | In this review, the nature of the ganglioside clusters and how gangliosides behave in the clusters leading to the GAbeta generation are discussed. | Gangliosides | alpha glucosidase | Homo sapiens |
| 5 | In this review, the nature of the ganglioside clusters and how gangliosides behave in the clusters leading to the GAbeta generation are discussed. | Gangliosides | alpha glucosidase | Homo sapiens |