Pub. Date : 1990 Nov 15
PMID : 2121335
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metabolism of diaziquone by NAD(P)H:(quinone acceptor) oxidoreductase (DT-diaphorase): role in diaziquone-induced DNA damage and cytotoxicity in human colon carcinoma cells. | diaziquone | NAD(P)H quinone dehydrogenase 1 | Homo sapiens |
| 2 | Metabolism of diaziquone by NAD(P)H:(quinone acceptor) oxidoreductase (DT-diaphorase): role in diaziquone-induced DNA damage and cytotoxicity in human colon carcinoma cells. | diaziquone | NAD(P)H quinone dehydrogenase 1 | Homo sapiens |
| 3 | AZQ (0-20 microM) induced dicumarol-inhibitable DNA interstrand cross-linking and cytotoxicity in HT-29 human colon carcinoma cells which have high DT-diaphorase activity but not in BE cells which have low DT-diaphorase activity. | diaziquone | NAD(P)H quinone dehydrogenase 1 | Homo sapiens |
| 4 | AZQ (0-20 microM) induced dicumarol-inhibitable DNA interstrand cross-linking and cytotoxicity in HT-29 human colon carcinoma cells which have high DT-diaphorase activity but not in BE cells which have low DT-diaphorase activity. | diaziquone | NAD(P)H quinone dehydrogenase 1 | Homo sapiens |
| 5 | DT-diaphorase was purified from HT-29 cells and metabolism of AZQ by this enzyme was confirmed. | diaziquone | NAD(P)H quinone dehydrogenase 1 | Homo sapiens |
| 6 | These data show that AZQ can be metabolized by purified rat hepatic and human HT-29 DT-diaphorase and suggest that in HT-29 cells, DT-diaphorase catalyzed reduction of AZQ represents a bioactivation process leading to the production of genotoxic and cytotoxic metabolites. | diaziquone | NAD(P)H quinone dehydrogenase 1 | Homo sapiens |
| 7 | These data show that AZQ can be metabolized by purified rat hepatic and human HT-29 DT-diaphorase and suggest that in HT-29 cells, DT-diaphorase catalyzed reduction of AZQ represents a bioactivation process leading to the production of genotoxic and cytotoxic metabolites. | diaziquone | NAD(P)H quinone dehydrogenase 1 | Homo sapiens |
| 8 | These data show that AZQ can be metabolized by purified rat hepatic and human HT-29 DT-diaphorase and suggest that in HT-29 cells, DT-diaphorase catalyzed reduction of AZQ represents a bioactivation process leading to the production of genotoxic and cytotoxic metabolites. | diaziquone | NAD(P)H quinone dehydrogenase 1 | Homo sapiens |
| 9 | These data show that AZQ can be metabolized by purified rat hepatic and human HT-29 DT-diaphorase and suggest that in HT-29 cells, DT-diaphorase catalyzed reduction of AZQ represents a bioactivation process leading to the production of genotoxic and cytotoxic metabolites. | diaziquone | NAD(P)H quinone dehydrogenase 1 | Homo sapiens |