Pub. Date : 2011 Jan 6
PMID : 21211036
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BACKGROUND: A genome-wide association study (GWAS) using metabolite concentrations as proxies for enzymatic activity, suggested that two variants: rs2014355 in the gene encoding short-chain acyl-coenzyme A dehydrogenase (ACADS) and rs11161510 in the gene encoding medium-chain acyl-coenzyme A dehydrogenase (ACADM) impair fatty acid beta-oxidation. | Fatty Acids | acyl-CoA dehydrogenase short chain | Homo sapiens |
| 2 | CONCLUSIONS: In glucose-tolerant individuals the minor C-allele of rs2014355 of ACADS was associated with reduced measures of glucose-stimulated insulin release during an OGTT, a finding which in part may be mediated through an impaired beta-oxidation of fatty acids. | Fatty Acids | acyl-CoA dehydrogenase short chain | Homo sapiens |