Title : A novel protein kinase D phosphorylation site in the tumor suppressor Rab interactor 1 is critical for coordination of cell migration.

Pub. Date : 2011 Mar 1

PMID : 21209314






4 Functional Relationships(s)
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1 Protein kinase D (PKD) phosphorylates RIN1 at serine 351 in vitro, thereby regulating interaction with 14-3-3 proteins. Serine Ras and Rab interactor 1 Homo sapiens
2 Here, we report the identification of serine 292 in RIN1 as an in vivo PKD phosphorylation site. Serine Ras and Rab interactor 1 Homo sapiens
3 We demonstrate that phosphorylation at serine 292 controls RIN1-mediated inhibition of cell migration by modulating the activation of Abl kinases. Serine Ras and Rab interactor 1 Homo sapiens
4 We further provide evidence that RIN1 in vivo phosphorylation at serine 351 occurs independently of PKD. Serine Ras and Rab interactor 1 Homo sapiens