Pub. Date : 2011 Dec
PMID : 21209237
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Pegvisomant is a growth hormone (GH) receptor antagonist that normalizes insulin-like growth factor I (IGF-I) levels in patients with acromegaly. | pegvisomant | insulin like growth factor 1 | Homo sapiens |
| 2 | Pegvisomant is a growth hormone (GH) receptor antagonist that normalizes insulin-like growth factor I (IGF-I) levels in patients with acromegaly. | pegvisomant | insulin like growth factor 1 | Homo sapiens |
| 3 | Although the dose of pegvisomant is determined by the IGF-I level, the pharmacokinetic and pharmacodynamic (PK/PD) model for pegvisomant concentration and IGF-I reduction has not been established. | pegvisomant | insulin like growth factor 1 | Homo sapiens |
| 4 | A sigmoid E(max) model adequately described the relationship between IGF-I and pegvisomant concentrations. | pegvisomant | insulin like growth factor 1 | Homo sapiens |