Title : mTORC1-S6K activation by endotoxin contributes to cytokine up-regulation and early lethality in animals.

Pub. Date : 2010 Dec 21

PMID : 21200439






1 Functional Relationships(s)
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1 We found that mTORC1-S6K suppression by rapamycin delayed mortality of mice challenged with lethal endotoxin, and was associated with dampened circulating levels of VEGF, IL-1beta, IFN-gamma and IL-5. Sirolimus interferon gamma Mus musculus