Title : Neisseria meningitidis capsular polysaccharides induce inflammatory responses via TLR2 and TLR4-MD-2.

Pub. Date : 2011 Mar

PMID : 21191086






2 Functional Relationships(s)
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1 A significant reduction in TNF-alpha and IL-8 release was seen when THP-1- and HEK-TLR4/MD-2-CD14- but not HEK-TLR2- or HEK-TLR2/6-transfected cells were stimulated with CPS in the presence of Eritoran (E5564), a lipid A antagonist that binds to MD-2, and a similar reduction in NO and TNF-alpha release was also seen in RAW 264.7 cells in the presence of Eritoran. eritoran Eph receptor A3 Mus musculus
2 A significant reduction in TNF-alpha and IL-8 release was seen when THP-1- and HEK-TLR4/MD-2-CD14- but not HEK-TLR2- or HEK-TLR2/6-transfected cells were stimulated with CPS in the presence of Eritoran (E5564), a lipid A antagonist that binds to MD-2, and a similar reduction in NO and TNF-alpha release was also seen in RAW 264.7 cells in the presence of Eritoran. eritoran Eph receptor A3 Mus musculus