Title : 2,4-Diaminopyrimidine inhibitors of c-Met kinase bearing benzoxazepine anilines.

Pub. Date : 2011 Jan 15

PMID : 21190849






1 Functional Relationships(s)
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1 Elaboration of the SAR around a series of 2,4-diaminopyrimidines led to a number of c-Met inhibitors in which kinase selectivity was modulated by substituents appended on the C4-aminobenzamide ring and the nature of the C2-aminoaryl ring. anthranilamide sarcosinemia autosomal recessive Mus musculus