CPRiL

3 Functional Relationships(s) Download
	Sentence	Compound Name	Protein Name	Organism
1	METHODS: After primarily cultured rat PASMCs was treated with AG490 and then exposed to hypoxia, the tyrosine-phosphorylated STAT3 protein were detected at 2 h, 6 h, 12 h, 16 h, 24 h of exposure to hypoxia by semi-quantitive RT-PCR (sqRT-PCR) and Western blot respectively.	Tyrosine	signal transducer and activator of transcription 3	Rattus norvegicus
2	RESULTS: The level of tyrosine-phosphorylated STAT3 increased at 6 h and peaked at 12 h. The expression of c-myc mRNA increased after 2 h of hypoxia and reached maximal level at 4 h, then declined at 6 h and to the basal levels at 12 h. With the prolonging of hypoxia time, 3H-TdR incorporation in PASMC under hypoxia conditions was significantly higher.	Tyrosine	signal transducer and activator of transcription 3	Rattus norvegicus
3	AG490 inhibited proliferation of PASMCs by preventing STAT3 tyrosine phosphorylation and the expression of c-myc under hypoxia conditions.	Tyrosine	signal transducer and activator of transcription 3	Rattus norvegicus