Title : Valproate uncompetitively inhibits arachidonic acid acylation by rat acyl-CoA synthetase 4: relevance to valproate's efficacy against bipolar disorder.

Pub. Date : 2011 Mar

PMID : 21184843






1 Functional Relationships(s)
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1 RESULTS: VPA uncompetitively inhibited Acsl4-mediated conversion of AA and of docosahexaenoic (DHA) but not of palmitic acid to acyl-CoA, but did not affect AA conversion by Acsl3, Acsl6v1 or Acsl6v2. docosahexaenoic acyl-CoA synthetase long-chain family member 4 Rattus norvegicus