Title : Repaglinide-gemfibrozil drug interaction: inhibition of repaglinide glucuronidation as a potential additional contributing mechanism.

Pub. Date : 2010 Dec

PMID : 21175442






1 Functional Relationships(s)
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1 CONCLUSIONS: Inhibition of UGT enzymes, especially UGT1A1, by gemfibrozil and its glucuronide is an additional mechanism to consider when rationalizing the interaction between repaglinide and gemfibrozil. Glucuronides UDP glucuronosyltransferase family 1 member A1 Homo sapiens