Pub. Date : 2011 Feb
PMID : 21171084
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In the adenomas from DMH-treated K-ras{Val12} mice, K-ras{Val12} transgene recombination and expression were confirmed, with immunohistochemical evidence of strong Erk/MapK and mild PI3K/Akt pathway activation compared with adenomas from DMH-treated wild-type mice. | 1,2-Dimethylhydrazine | Kirsten rat sarcoma viral oncogene homolog | Mus musculus |
| 2 | In the adenomas from DMH-treated K-ras{Val12} mice, K-ras{Val12} transgene recombination and expression were confirmed, with immunohistochemical evidence of strong Erk/MapK and mild PI3K/Akt pathway activation compared with adenomas from DMH-treated wild-type mice. | 1,2-Dimethylhydrazine | Kirsten rat sarcoma viral oncogene homolog | Mus musculus |
| 3 | Microarray hybridization and clustering analysis demonstrated different expression profiles in adenomas from DMH-treated wild-type and DMH-treated K-ras{Val12} mice, indicating involvement of different molecular mechanisms including Erk/MapK and PI3K/Akt signalling in K-ras{Val12}-expressing adenomas. | 1,2-Dimethylhydrazine | Kirsten rat sarcoma viral oncogene homolog | Mus musculus |
| 4 | Microarray hybridization and clustering analysis demonstrated different expression profiles in adenomas from DMH-treated wild-type and DMH-treated K-ras{Val12} mice, indicating involvement of different molecular mechanisms including Erk/MapK and PI3K/Akt signalling in K-ras{Val12}-expressing adenomas. | 1,2-Dimethylhydrazine | Kirsten rat sarcoma viral oncogene homolog | Mus musculus |
| 5 | Microarray hybridization and clustering analysis demonstrated different expression profiles in adenomas from DMH-treated wild-type and DMH-treated K-ras{Val12} mice, indicating involvement of different molecular mechanisms including Erk/MapK and PI3K/Akt signalling in K-ras{Val12}-expressing adenomas. | 1,2-Dimethylhydrazine | Kirsten rat sarcoma viral oncogene homolog | Mus musculus |
| 6 | Microarray hybridization and clustering analysis demonstrated different expression profiles in adenomas from DMH-treated wild-type and DMH-treated K-ras{Val12} mice, indicating involvement of different molecular mechanisms including Erk/MapK and PI3K/Akt signalling in K-ras{Val12}-expressing adenomas. | 1,2-Dimethylhydrazine | Kirsten rat sarcoma viral oncogene homolog | Mus musculus |
| 7 | Array-comparative genomic hybridization analysis showed chromosome stability in both cohorts, with only a very few tiny alterations observed in one adenoma from a DMH-treated K-ras{Val12} mouse. | 1,2-Dimethylhydrazine | Kirsten rat sarcoma viral oncogene homolog | Mus musculus |
| 8 | Taken together, these data show that mutant K-ras significantly promotes DMH-induced colorectal tumourigenesis, resulting in distinct changes in cell signalling and proliferation, but does not alter chromosome stability in the tumours. | 1,2-Dimethylhydrazine | Kirsten rat sarcoma viral oncogene homolog | Mus musculus |