Pub. Date : 2011 Mar 1
PMID : 21168393
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Modulation of Rad51, ERCC1, and thymidine phosphorylase by emodin result in synergistic cytotoxic effect in combination with capecitabine. | Capecitabine | RAD51 recombinase | Homo sapiens |
| 2 | Accordingly, we aimed to explore the molecular mechanism of emodin enhances the capecitabine-induced cytotoxicity through controlling Rad51, ERCC1, and TP expression in human non-small cell lung cancer (NSCLC). | Capecitabine | RAD51 recombinase | Homo sapiens |
| 3 | The results show that capecitabine increases the phosphorylation of MKK1/2-ERK1/2 and protein levels of Rad51 and ERCC1 through enhancing the protein stability. | Capecitabine | RAD51 recombinase | Homo sapiens |
| 4 | Depletion of endogenous Rad51 or ERCC1 expression by specific small interfering RNA transfection significantly increases capecitabine-induced cell death and growth inhibition. | Capecitabine | RAD51 recombinase | Homo sapiens |
| 5 | Emodin enhances the capecitabine-induced cytotoxic effects through ERK1/2 inactivation and decreasing the Rad51 and ERCC1 protein levels induced by capecitabine. | Capecitabine | RAD51 recombinase | Homo sapiens |
| 6 | We conclude that enhancing the cytotoxicity to capecitabine by emodin is mediated by down-regulation the expression of Rad51 and ERCC1 and up-regulation TP expression. | Capecitabine | RAD51 recombinase | Homo sapiens |