Title : Solution NMR structure of Apo-calmodulin in complex with the IQ motif of human cardiac sodium channel NaV1.5.

Pub. Date : 2011 Feb 11

PMID : 21167176






3 Functional Relationships(s)
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Protein Name
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1 The function of the human voltage-gated sodium channel Na(V)1.5 is regulated in part by intracellular calcium signals. Calcium immunoglobulin lambda variable 2-18 Homo sapiens
2 The ubiquitous calcium sensor protein calmodulin (CaM) is an important part of the complex calcium-sensing apparatus in Na(V)1.5. Calcium immunoglobulin lambda variable 2-18 Homo sapiens
3 Sequence similarities between voltage-gated sodium channels and voltage-gated calcium channels suggest that the structure of the CaM-Na(V)1.5 IQ motif complex can serve as a general model for the interaction between CaM and ion channel IQ motifs under low-calcium conditions. Calcium immunoglobulin lambda variable 2-18 Homo sapiens