Pub. Date : 2011 Mar
PMID : 21164517
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The novel JAK inhibitor AZD1480 blocks STAT3 and FGFR3 signaling, resulting in suppression of human myeloma cell growth and survival. | AZD 1480 | signal transducer and activator of transcription 3 | Homo sapiens |
| 2 | These biological responses to AZD1480 are associated with concomitant inhibition of phosphorylation of JAK2, STAT3 and MAPK signaling proteins. | AZD 1480 | signal transducer and activator of transcription 3 | Homo sapiens |
| 3 | In sum, AZD1480 blocks proliferation, survival, FGFR3 and JAK/STAT3 signaling in myeloma cells cultured alone or cocultured with BM stromal cells, and in vivo. | AZD 1480 | signal transducer and activator of transcription 3 | Homo sapiens |