Title : Prenatal androgenization of female mice programs an increase in firing activity of gonadotropin-releasing hormone (GnRH) neurons that is reversed by metformin treatment in adulthood.

Pub. Date : 2011 Feb

PMID : 21159854






4 Functional Relationships(s)
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1 Prenatal androgenization of female mice programs an increase in firing activity of gonadotropin-releasing hormone (GnRH) neurons that is reversed by metformin treatment in adulthood. Metformin gonadotropin releasing hormone 1 Mus musculus
2 Prenatal androgenization of female mice programs an increase in firing activity of gonadotropin-releasing hormone (GnRH) neurons that is reversed by metformin treatment in adulthood. Metformin gonadotropin releasing hormone 1 Mus musculus
3 To assess whether AMPK activation contributed to the metformin-induced reduction in GnRH neuron activity, the AMPK antagonist compound C was acutely applied to cells. Metformin gonadotropin releasing hormone 1 Mus musculus
4 GnRH neurons from metformin-treated mice also showed a reduced inhibitory response to low glucose. Metformin gonadotropin releasing hormone 1 Mus musculus