Title : Inhibitory mechanisms of two Uncaria tomentosa extracts affecting the Wnt-signaling pathway.

Pub. Date : 2011 Jun 15

PMID : 21156346






1 Functional Relationships(s)
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1 We show that both, an aqueous and an alkaloid-enriched extract specifically inhibit Wnt-signaling activity in HeLa, HCT116 and SW480 cancer cells resulting in reduced expression of the Wnt-target gene: c-Myc. Alkaloids MYC proto-oncogene, bHLH transcription factor Homo sapiens