Pub. Date : 2010 Nov 30
PMID : 21152094
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BACKGROUND: One of the earliest activation events following stimulation of the T cell receptor (TCR) is the phosphorylation of the immunoreceptor tyrosine-based activation motifs (ITAMs) within the CD3-associated complex by the Src family kinase Lck. | Tyrosine | T cell receptor beta variable 20/OR9-2 (non-functional) | Homo sapiens |
| 2 | BACKGROUND: One of the earliest activation events following stimulation of the T cell receptor (TCR) is the phosphorylation of the immunoreceptor tyrosine-based activation motifs (ITAMs) within the CD3-associated complex by the Src family kinase Lck. | Tyrosine | T cell receptor beta variable 20/OR9-2 (non-functional) | Homo sapiens |
| 3 | TCR stimulation led to the co-precipitation of Lck with the transmembrane adaptor protein LAT (linker for activation of T cells), Erk-mediated phosphorylation of Lck and no detectable dephosphorylation of Lck inhibitory tyrosine. | Tyrosine | T cell receptor beta variable 20/OR9-2 (non-functional) | Homo sapiens |
| 4 | Strikingly, upon LAT knockdown in Hut-78 cells, we found that LAT promoted TCR-induced phosphorylation of Lck and Fyn activatory tyrosines, TCRzeta chain phosphorylation and Zap-70 activation. | Tyrosine | T cell receptor beta variable 20/OR9-2 (non-functional) | Homo sapiens |