Title : Affinity and translocation relationships via hPEPT1 of H-X aa-Ser-OH dipeptides: evaluation of H-Phe-Ser-OH as a pro-moiety for ibuprofen and benzoic acid prodrugs.

Pub. Date : 2011 Feb

PMID : 21147219

1 Functional Relationships(s)
Compound Name
Protein Name
1 The K(i)-values of H-X(aa)-Ser-OH dipeptides for hPEPT1 in MDCK/hPEPT1 cells ranged from 0.14 mM (logIC(50)=-0.85 +- 0.06) for H-Tyr-Ser-OH to 0.89 mM (logIC(50)=-0.09 +- 0.02) for H-Gly-Ser-OH, as measured in a competition assay with [(14)C]Gly-Sar. Glycine solute carrier family 15 member 1 Homo sapiens